The area was settled by various cultures of indigenous peoples for thousands of years before European colonization. The "Indian Road" refers to a historic pathway made by local tribes.
European Americans established Frederick County in 1743 from Orange County. The county was named for Frederick Lewis, Prince of Wales and eldest son of King George II of Great Britain.
During the Revolutionary War, General George Washington's headquarters were located in Winchester. Washington represented Frederick County in his first elective offices, having been elected to the House of Burgesses in 1758 and 1761.
Hardy County, West Virginia
Hampshire County, Virginia (now West Virginia)
Morgan County, West Virginia
Berkeley County, West Virginia
Independent City of Winchester